Publications

36. Duti, I. J.; Paul, J.+; Reilly, K. S.+; Miller, D. R.; Dickie, D. A.; Letteri, R. A. Peptide stereocomplex cross-links for polymer hydrogels. Chem. Sci. 2025, 16, 11931-11938. DOI: 10.1039/D5SC00251F

35. Cui, Z.; Brna, E. A.+; Crawford, M. A.; Treerat, P.; Alimadad, M.; Hughes, M. A.; Letteri, R. A.* Presenting Antimicrobial Peptides on Poly(ethylene glycol): Star-shaped vs. Comb-Like Architectures. Macromolecules 2025, 58, 4, 2073-2084. DOI: 10.1021/acs.macromol.4c02762 (Impact factor: 5.1)

34. Estrella-You, A.; Duti, I. J.; Luo, Q.; Harris, J. D.; Letteri, R. A.; Smith, J. A.* N-Chloramine Functionalized Polymer Gels for Point-of-Use Water Disinfection. Water 2024, 16, 3128.  DOI: 10.3390/w16213128

33. Bannon, M. S.; Ellena, J. F.; Gourishankar, A. S.; Marsh, S. R.; Trevisan-Silva, D.; Sherman, N. E.; Jourdan, L. J.; Gourdie, R.; Letteri, R. A.* Multi-site esterification: A tunable, reversible strategy to tailor therapeutic peptides for delivery. Mol. Sys. Des. Eng. 2024.  DOI: 10.1039/D4ME00072B 

32. Verma, P. V.‡; Bannon, M. S.‡; Kuenen, M. K.; Raj, S.; Dhakal, A.; Stone, K.; Nichols, A. S.; Machan, C. W.; Colón, Y. J.; Letteri, R. A.*; Giri, G.* Expanding the Design Space of Polymer–Metal Organic Framework (MOF) Gels by Understanding Polymer–MOF Interactions. Chem. Mater. 2024, 36, 19, 9356-9369.  DOI: 10.1021/acs.chemmater.4c00112 

31. Gray, V. P.; Letteri, R. A.* Designing coiled coils for heterochiral complexation to enhance binding and enzymatic stability. Biomacromolecules 2024, 25, 5273-5280.  DOI: 10.1021/acs.biomac.4c00661 

30. Cui, Z.; Crawford, M. A.; Rumble, B. A.; Krogh, M. M.; Hughes, M. A.; Letteri, R. A.*  Antimicrobial peptide-poly(ethylene glycol) conjugates: connecting molecular architecture, solution properties, and functional performance.  ACS Polym. Au 2024, 4, 45-55.  DOI: 10.1021/acspolymersau.3c00026 

29. Kuenen, M.K.; Reilly, K. S. +; Letteri, R. A*. Elucidating the effects of amine charge state on poly(β-amino ester) degradation using permamently charged analogs. ACS Macro Lett. 2023, 12, 1416-1422. DOI: 10.1021/acsmacrolett.3c00440

28. Duti, I. J.; Florian, J. R.; Kittel, A. R.; Amelung, C. D.; Gray, V. P.; Lampe, K. J.*; Letteri, R. A.* Peptide stereocomplexation orchestrates supramolecular assembly of hydrogel biomaterials. J. Am. Chem. Soc. 2023, 145, 18468-18476. DOI: 10.1021/jacs.3c04872 *co-corresponding authors

27. Kuenen, M. K.; Cuomo, A. M. +; Gray, V. P.; Letteri, R. A.* Net anionic poly(β-amino ester)s: synthesis, pH-dependent behavior, and complexation with cationic cargo. Polym. Chem. 2023, 14, 421-431. DOI: 10.1039/DPY01319C

26. Crawford, M.; Ward, A.; Gray, V. P.; Bailer, P.; Fisher, D.; Kubicka, E.; Cui, Z.; Luo, Q.; Gray, M.; Criss, A.; Lum, L.; Tamm, L.; Letteri, R. A.; Hughes, M. Disparate regions of the human chemokine CXCL10 exhibit broad-spectrum antimicrobial activity against biodefense and antibiotic-resistant bacterial pathogens. ACS Infect. Dis. 2023, 9, 122-139.

25. Gray, V. P.; Amelung, C. D.; Duti, I. J.; Laudermilch, E. G.; Letteri, R. A.*; Lampe, K. J.* Biomaterials via peptide assembly: Design, characterization, and application in tissue engineering. Acta Biomaterialia 2022, 140, 43-75. DOI: 10.1016/j.actbio.2021.10.030 *co-corresponding authors

24. Kuenen, M. K.; Mullin, J. A.; Letteri, R. A*. Buffering effects on the solution behavior and hydrolytic degradation of poly(β-amino ester)s. J. Polym. Sci. 2021, DOI: 10.1002/pol.20210377 

23. Cui, Z.; Luo, Q.; Bannon, M. S.; Gray, V. P.; Bloom, T. G.; Clore, M. F.; Hughes, M. A.; Crawford, M. A.; Letteri, R.A*. Molecular Engineering of antimicrobial peptide (AMP)-polymer conjugates. Biomaterials Sci. 2021, 9, 5069-5091. DOI: 10.1039/D1BM00423A *Corresponding author

22. Grewal, M. G.; Gray, V. P.; Letteri, R. A.; Highey, C.B*. User-defined, temporal presentation of bioactive molecules on hydrogel substrates using supramolecular coiled coil complexes. Biomaterials Sci. 2021, 9, 4374-4387. DOI: 10.1039/D1BM00016K

Prior to UVa

21. Figueiredo, M. L.; Letteri, R.; Chan-Seng, D.; Kumar, S.; Rivera-Cruz, C. M.; Emrick, T. S. Reengineering tumor microenvironment with sequential interleukin delivery. Bioengineering 2021, 8, 90, DOI: 10.3390/bioengineering8070090

20. Song, Y.; Elsabahy, M.; Collins, C. A.; Khan, S.; Li, R.; Hreha, T. N.; Shen, Y.; Lin, Y.-N.; Letteri, R. A.; Su, L.; Dong, M.; Zhang, F.; Hunstad, D. A.; Wooley, K. L. Morphologic design of silver-bearing sugar-based polymer nanoparticles for uroepithelial cell binding and antimicrobial delivery. Nano Lett. 2021, 21, 4990-4998. DOI: 10.1021/acs.nanolett.1c00776

19. Nguyen, T. P.; Easley, A. D.; Kang, N.; Khan, S.; Lim, S.-M.; Rezenom, Y. H.; Wang, S.; Tran, D. K.; Fan, J.; Letteri, R. A.; He, X.; Su, L.; Yu, C.-H.; Lutkenhaus, J. L.; Wooley, K.L.  Polypeptide organic radical batteries. Nature 2021, 593, 61-66.  DOI: 10.1038/s41586-021-03399-1

18. Lin, Y.-N.; Elsabahy, M.; Khan, S.; Zhang, F.; Song, Y.; Dong, M.; Li, R.; Smolen, J.; Letteri, R. A.; Su, L.; Wooley, K. L.  Erythrocyte membrane-camouflaged nanocarriers with tunable paclitaxel release kinetics via macromolecular stereocomplexation. ACS Materials Lett. 2, 595-601.  DOI: 10.1021/acsmaterialslett.0c00044

17. Figueiredo, M. L.; Figueiredo Neto, M.; Salameh, J. W.; Decker, R.E.; Letteri, R.; Chan-Seng, D.; Emrick T. Ligand-mediated targeting of cytokine Interleukin-27 enhances its bioactivity in vivo. Molecular Therapy: Methods & Clinical Development 2020, 17, 739-751.  DOI: 10.1016/j.omtm.2020.03.022

16. Dong, M.; Song, Y.; Wang, H.; Su, L.; Chen, Y.; Tran, D. K.; Letteri, R. A.; Flores, J. A.; Lin, Y.-N.; Li, J.; Wooley, K. L. Degradable sugar-based magnetic hybrid nanoparticles for recovery of crude oil from aqueous environments. Polym. Chem. 2020, 11, 4895-4903.  DOI: 10.1039/D0PY00029A.

15. Dong, M.;* Wessels, M. G.;* Lee, J. Y.; Su, L.; Wang, H.; Letteri, R. A.; Song, Y.; Lin, Y.-N.; Chen, Y.; Li, R.; Pochan, D. J.; Jayaraman, A.; Wooley, K. L.  Experiments and Simulations of Complex Sugar-Based Coil-Brush Block Polymer Nanoassemblies in Aqueous Solution.  ACS Nano 2019, 13, 6147-6162.  DOI: 10.1021/acsnano.8b08811

14. Hahm, S.; Kim, J.-S.; Yun, H.; Park, J. H.; Letteri, R. A.; Kim, B. J.  Bench-scale synthesis and characterization of biodegradable aliphatic-aromatic random copolymers with 1,4-cyclohexanedimethanol units toward sustainable packaging applications.  ACS Sustainable Chem. Eng. 2019, 7, 4734-4743, DOI: 10.1021/acssuschemeng.8b04720

13. Li, R.; Elsabahy, M.; Song, Y.; Wang, H.; Su, L.; Letteri, R. A.; Khan, S.; Heo, G. S.; Sun, G.; Liu, Y.; Wooley, K. L.  Functional, degradable zwitterionic polyphosphoesters as biocompatible coating materials for metal nanostructures.  Langmuir 2019, 35, 1503-1512, DOI: 10.1021/acs.langmuir.8b02033

12. Santa Chalarca, C. F.; Letteri, R. A.; Perazzo, A.; Stone, H.; Emrick T.  Building supracolloidal fibers from zwitterion-stabilized adhesive emulsions.  Adv. Funct. Mater. 2018, 1804325, DOI: 10.1002/adfm.201804325

11. Kalasin, S.; Letteri, R. A.; Emrick, T.; Santore, M. M.  Adsorbed polyzwitterion copolymer layers designed for protein repellency and interfacial retention.  Langmuir 2017, 33, 13708-13717.  DOI: 10.1021/acs.langmuir.7b03391

10. Johnston B. M.;+ Johnston, C.W.;+ Letteri, R.; Lytle, T. K.; Sing, C. E.; Emrick, T.; Perry, S. L.  The effect of comb architecture on complex coacervation.  Org. Biomol. Chem. 2017, 15, 7630-7642.  DOI: 10.1039/C7OB01314K, +undergraduate authors

9. Letteri, R. A.;* Santa Chalarca, C. F;* Bai, Y.; Hayward, R. C.; Emrick, T.  Forming sticky droplets from slippery polymer zwitterions.  Adv. Mater. 2017, 1702921.  DOI: 10.1002/adma.201702921, *Equal contributors

8. Song, Y.; Chen, Y.; Li, R.; Su, L.; Letteri, R. A.; Wooley, K. L.  Crystallization-driven assembly of fully degradable, natural product-based poly(l-lactide)-block-poly(α-d-glucose carbonate)s in aqueous solution.  Polymer 2017, 122, 270-279.  DOI: 10.1016/j.polymer.2017.06.065

7. Fan, J.; Li, R.; Wang, H.; He, X.; Nguyen, T. P.; Letteri, R. A.; Zou, J.; Wooley, K. L.  Multi-responsive polypeptide hydrogels derived from N-carboxyanhydride terpolymerizations for delivery of nonsteroidal anti-inflammatory drugs.  Org. Biomol. Chem. 2017, 15, 5145-5154.  DOI: 10.1039/C7OB00931C

6. Zigmond, J. S.; Letteri, R. A.; Wooley, K. L.  Amphiphilic cross-linked liquid crystalline fluoropolymer-poly(ethylene glycol) coatings for application in challenging conditions:  Comparative study between different liquid crystalline comonomers and polymer architectures.  ACS Appl. Mater. Interfaces 2016, 8, 33386-33393.  DOI: 10.1021/acsami.6b11112

5. Ghobadi, A. F.;* Letteri, R.;* Parelkar, S. S.; Zhao, Y.; Chan-Seng, D.; Emrick, T.; Jayaraman, A.  Dispersing zwitterions into comb polymers for nonviral transfection:  Experiments and Molecular Simulation.  Biomacromolecules 2016, 17, 546-557.  DOI: 0.1021/acs.biomac.5b01462, *Equal contributors

4. Chang, C. C.;* Letteri, R.;* Hayward, R. C.; Emrick, T.  Functional sulfobetaine polymers:  Synthesis and salt-responsive stabilization of oil-in-water droplets.  Macromolecules 2015, 48, 7843-7850.  DOI: 10.1021/acs.macromol.5b01861, *Equal contributors

3. Neto, M. F.; Letteri, R.; Chan-Seng, D.; Emrick, T.; Figueiredo, M. L.  Sonodelivery facilitates sustained luciferase expression from an episomal vector in skeletal muscle.  Materials 2015, 8, 4608-4617.  DOI: 10.3390/ma8074608

2. Parelkar, S. S.;* Letteri, R.;* Chan-Seng, D.;* Zolochevska, O.; Ellis, J.; Figueiredo, M.; Emrick, T.  Polymer-peptide delivery platofrms: Effect of oligopeptide orientation on polymer-based DNA delivery.  Biomacromolecules 2014, 15, 1328-1336.  DOI: 10.1021/bm401878p, *Equal contributors

1. Han, D.; Letteri, R.; Chan-Seng, D.; Emrick T.; Tu, H. Examination of zwitterionic polymers and gels subjected to mechanical constraints.  Polymer 2013, 54, 2887-2894.  DOI: 10.1016/j.polymer.2013.04.003